| Sep 12 CIN @ NE | 1:00 PM | |
| Sep 19 BAL @ CIN | 1:00 PM | |
| Sep 26 CIN @ CAR | 1:00 PM | |
| Oct 03 CIN @ CLE | 1:00 PM | |
| Oct 10 TB @ CIN | 1:00 PM | |
| Bye | - | |
| Oct 24 CIN @ ATL | 1:00 PM | |
| Oct 31 MIA @ CIN | 1:00 PM | |
| Nov 08 PIT @ CIN | 8:30 PM | |
| Nov 14 CIN @ IND | 1:00 PM | |
| Nov 21 BUF @ CIN | 1:00 PM | |
| Nov 25 CIN @ NYJ | 8:20 PM | |
| Dec 05 NO @ CIN | 1:00 PM | |
| Dec 12 CIN @ PIT | 1:00 PM | |
| Dec 19 CLE @ CIN | 1:00 PM | |
| Dec 26 SD @ CIN | 8:20 PM | |
| Jan 02 CIN @ BAL | 1:00 PM | |
| Sep 13 DEN @ CIN | L 7-12 (0-1) | |
| Sep 20 CIN @ GB | W 31-24 (1-1) | |
| Sep 27 PIT @ CIN | W 23-20 (2-1) | |
| Oct 04 CIN @ CLE | W 23-20 (3-1) | |
| Oct 11 CIN @ BAL | W 17-14 (4-1) | |
| Oct 18 HOU @ CIN | L 17-28 (4-2) | |
| Oct 25 CHI @ CIN | W 45-10 (5-2) | |
| Bye | Bye | |
| Nov 08 BAL @ CIN | W 17-7 (6-2) | |
| Nov 15 CIN @ PIT | W 18-12 (7-2) | |
| Nov 22 CIN @ OAK | L 17-20 (7-3) | |
| Nov 29 CLE @ CIN | W 16-7 (8-3) | |
| Dec 06 DET @ CIN | W 23-13 (9-3) | |
| Dec 13 CIN @ MIN | L 10-30 (9-4) | |
| Dec 20 CIN @ SD | L 24-27 (9-5) | |
| Dec 27 KC @ CIN | W 17-10 (10-5) | |
| Jan 03 CIN @ NYJ | L 0-37 (10-6) | |
| Jan 09 NYJ @ CIN Wildcard | L 14-24 (10-7) | |
| Sept. 7 at Baltimore Ravens 1 p.m. | L 10-17 (0-1) | |
| Sept. 14 Tennessee Titans 1 p.m. | L 7-24 (0-2) | |
| Sept. 21 at New York Giants 1 p.m. | L 23-26 (0-3) | |
| Sept. 28 Cleveland Browns 1 p.m. | L 12-20 (0-4) | |
| Oct. 5 at Dallas Cowboys 4:15 p.m. | L 22-31 (0-5) | |
| Oct. 12 at New York Jets 1 p.m. | L 14-26 (0-6) | |
| Oct. 19 Pittsburgh Steelers 1 p.m. | L 10-38 (0-7) | |
| Oct. 26 at Houston Texans 1 p.m. | L 6-35 (0-8) | |
| Nov. 2 Jacksonville Jaguars 1 p.m. | W 21-19 (1-8) | |
| Nov. 9 Bye | Bye | |
| Nov. 16 Philadelphia Eagles 1 p.m. | T 13-13 (1-8-1) | |
| Nov. 20 (Thurs.) at Pittsburgh Steelers 8:15 | L 10-27 (1-9-1) | |
| Nov. 30 Baltimore Ravens 1 p.m. | L 3-34 (1-10-1) | |
| Dec. 7 at Indianapolis Colts 1 p.m. | L 3-35 (1-11-1) | |
| Dec. 14 Washington Redskins 1 p.m. | W 20-13 (2-11-1) | |
| Dec. 21 at Cleveland Browns 1 p.m. | W 14-0 (3-11-1) | |
| Dec. 28 Kansas City Chiefs 1 p.m. | W 16-6 (4-11-1) | |
| Mon. 9/10 vs. Ravens | W 27-20 (1-0) | |
| Sun. 9/16 @ Browns | L 51-45 (1-1) | |
| Sun. 9/23 @ Seahawks | L 21-24 (1-2) | |
| Mon. 10/1 vs. Patriots | L 13-34 (1-3) | |
| Sun. 10/7 Bye | BYE | |
| Sun. 10/14 @ Chiefs | L 20-27 (1-4) | |
| Sun. 10/21 vs. Jets | W 38-31 (2-4) | |
| Sun. 10/28 vs. Steelers | L 13-24 (2-5) | |
| Sun. 11/4 @ Bills | L 21-33 (2-6) | |
| Sun. 11/11 @ Ravens | W 21-7 (3-6) | |
| Sun 11/18 vs. Cardinals | L 27-35 (3-7) | |
| Sun. 11/25 @ Titans | W 35-6 (4-7) | |
| Sun. 12/2 @ Steelers | L 10-24 (4-8) | |
| Sun. 12/9 vs. Rams | W 19-10 (5-8) | |
| Sat. 12/15 @ 49ers | L 20-13 (5-9) | |
| Sun. 12/23 vs. Browns | W 19-14 (6-9) | |
| Sun. 12/30 @ Dolphins | W 38-25 (7-9) | |