
1970-present Buffalo Bills (NFL)
1960-1969 Buffalo Bills (AFL)
| Sep 12 MIA @ BUF | 1:00 PM | |
| Sep 19 BUF @ GB | 1:00 PM | |
| Sep 26 BUF @ NE | 1:00 PM | |
| Oct 03 NYJ @ BUF | 1:00 PM | |
| Oct 10 JAC @ BUF | 1:00 PM | |
| Bye | Bye | |
| Oct 24 BUF @ BAL | 1:00 PM | |
| Oct 31 BUF @ KC | 1:00 PM | |
| Nov 07 CHI @ BUF | 1:00 PM | |
| Nov 14 DET @ BUF | 1:00 PM | |
| Nov 21 BUF @ CIN | 1:00 PM | |
| Nov 28 PIT @ BUF | 1:00 PM | |
| Dec 05 BUF @ MIN | 1:00 PM | |
| Dec 12 CLE @ BUF | 1:00 PM | |
| Dec 19 BUF @ MIA | 1:00 PM | |
| Dec 26 NE @ BUF | 1:00 PM | |
| Jan 02 BUF @ NYJ | 1:00 PM | |
| Sep 14 BUF @ NE | L 24-25 (0-1) | |
| Sep 20 TB @ BUF | W 33-20 (1-1) | |
| Sep 27 NO @ BUF | L 7-27 (1-2) | |
| Oct 04 BUF @ MIA | L 10-38 (1-3) | |
| Oct 11 CLE @ BUF | L 3-6 (1-4) | |
| Oct 18 BUF @ NYJ | W 16-13 OT (2-4) | |
| Oct 25 BUF @ CAR | W 20-9 (3-4) | |
| Nov 01 HOU @ BUF | L 10-31 (3-5) | |
| Bye | Bye | |
| Nov 15 BUF @ TEN | L 17-41 (3-6) | |
| Nov 22 BUF @ JAC | L 15-18 (3-7) | |
| Nov 29 MIA @ BUF | W 31-14 (4-7) | |
| Dec 03 NYJ @ BUF | L 13-19 (4-8) | |
| Dec 13 BUF @ KC | W 16-10 (5-8) | |
| Dec 20 NE @ BUF | L 10-17 (5-9) | |
| Dec 27 BUF @ ATL | L 3-31 (5-10) | |
| Jan 03 IND @ BUF | W 30-7 (6-10) | |
| Sept. 7 Seattle Seahawks 1 p.m. | W 34-10 (1-0) | |
| Sept. 14 at Jacksonville Jaguars 1 p.m. | W 20-16 (2-0) | |
| Sept. 21 Oakland Raiders 1 p.m. | W 24-23 (3-0) | |
| Sept. 28 at St. Louis Rams 4:05 p.m. | W 31-14 (4-0) | |
| Oct. 5 at Arizona Cardinals 4:15 p.m. | L 17-41 (4-1) | |
| Oct. 12 Bye | Bye | |
| Oct. 19 San Diego Chargers 1 p.m. | W 23-14 (5-1) | |
| Oct. 19 at Miami Dolphins 1 p.m. | L 16-25 (5-2) | |
| Nov. 2 New York Jets 1 p.m. | L 17-26 (5-3) | |
| Nov. 9 at New England Patriots 1 p.m. | L 10-20 (5-4) | |
| Nov. 17 (Mon.) Cleveland Browns 8:30 p.m. | L 27-29 (5-5) | |
| Nov. 23 at Kansas City Chiefs 1 p.m. | W 54-31 (6-5) | |
| Nov. 30 San Francisco 49ers 1 p.m. | L 3-10 (6-6) | |
| Dec. 7 Miami Dolphins (at Toronto) 4:05 p.m. | L 3-16 (6-7) | |
| Dec. 14 at New York Jets 1 p.m. | L 27-31 (6-8) | |
| Dec. 21 at Denver Broncos 4:05 p.m. | W 30-23 (7-8) | |
| Dec. 28 New England Patriots 1 p.m. | L 0-13 (7-9) | |
| Sun. 9/9 vs. Broncos | L 14-15 (0-1) | |
| Sun. 9/16 @ Steelers | L 3-26 (0-2) | |
| Sun. 9/23 @ Patriots | L 7-38 (0-3) | |
| Sun. 9/30 vs. Jets | W 17-14 (1-3) | |
| Mon. 10/8 vs. Cowboys | L 24-25 (1-4) | |
| Sun. 10/14 Bye | BYE | |
| Sun. 10/21 vs. Ravens | W 19-14 (2-4) | |
| Sun. 10/28 @ Jets | W 13-3 (3-4) | |
| Sun. 11/4 vs. Bengals | W 33-21 (4-4) | |
| Sun. 11/11 @ Dolphins | W 13-10 (5-4) | |
| Sun. 11/18 vs. Patriots | L 10-56 (5-5) | |
| Sun. 11/25 @ Jaguars | L 14-36 (5-6) | |
| Sun. 12/2 @ Redskins | W 17-16 (6-6) | |
| Sun 12/9 vs. Dolphins | W 38-17 (7-6) | |
| Sun. 12/16 @ Browns | L 0-8 (7-7) | |
| Sun. 12/23 vs. Giants | L 21-38 (7-8) | |
| Sun. 12/30 @ Eagles | L 9-17 (7-9) | |