| Sep 12 IND @ HOU | 1:00 PM | |
| Sep 19 HOU @ WAS | 4:15 PM | |
| Sep 26 DAL @ HOU | 1:00 PM | |
| Oct 03 HOU @ OAK | 4:05 PM | |
| Oct 10 NYG @ HOU | 1:00 PM | |
| Oct 17 KC @ HOU | 1:00 PM | |
| Bye | - | |
| Nov 01 HOU @ IND | 8:30 PM | |
| Nov 07 SD @ HOU | 1:00 PM | |
| Nov 14 HOU @ JAC | 1:00 PM | |
| Nov 21 HOU @ NYJ | 1:00 PM | |
| Nov 28 TEN @ HOU | 1:00 PM | |
| Dec 02 HOU @ PHI | 8:20 PM | |
| Dec 13 BAL @ HOU | 8:30 PM | |
| 15 Dec 19 HOU @ TEN | 1:00 PM | |
| 16 Dec 26 HOU @ DEN | 4:05 PM | |
| 17 Jan 02 JAC @ HOU | 1:00 PM | |
| Sep 13 NYJ @ HOU | L 7-24 (0-1) | |
| Sep 20 HOU @ TEN | W 34-31 (1-1) | |
| Sep 27 JAC @ HOU | L 24-31 (1-2) | |
| Oct 04 OAK @ HOU | W 29-6 (2-2) | |
| Oct 11 HOU @ ARI | L 21-28 (2-3) | |
| Oct 18 HOU @ CIN | W 28-17 (3-3) | |
| Oct 25 SF @ HOU | W 24-21 (4-3) | |
| Nov 01 HOU @ BUF | W 31-10 (5-3) | |
| Nov 08 HOU @ IND | L 17-20 (5-4) | |
| Bye | Bye | |
| Nov 23 TEN @ HOU | L 17-20 (5-5) | |
| Nov 29 IND @ HOU | L 27-35 (5-6) | |
| Dec 06 HOU @ JAC | L 18-23 (5-7) | |
| Dec 13 SEA @ HOU | W 34-7 (6-7) | |
| Dec 20 HOU @ STL | W 16-13 (7-7) | |
| Dec 27 HOU @ MIA | W 27-20 (8-7) | |
| Jan 03 NE @ HOU | W 34-27 (9-7) | |
| Sept. 7 at Pittsburgh Steelers 1 p.m. | L 17-38 (0-1) | |
| Bye | Bye | |
| Sept. 21 at Tennessee Titans 1 p.m. | L 12-31 (0-2) | |
| Sept. 28 at Jacksonville Jaguars 1 p.m. | L 27-30 OT (0-3) | |
| Oct. 5 Indianapolis Colts 1 p.m. | L 27-31 (0-4) | |
| Oct. 12 Miami Dolphins 1 p.m. | W 29-28 (1-4) | |
| Oct. 19 Detroit Lions 4:05 p.m. | W 28-21 (2-4) | |
| Oct. 26 Cincinnati Bengals 1 p.m. | W 35-6 (3-4) | |
| Nov. 2 at Minnesota Vikings 1 p.m. | L 21-28 (3-5) | |
| Nov. 9 Baltimore Ravens | L 13-41 (3-6) | |
| Nov. 16 at Indianapolis Colts 1 p.m. | L 27-33 (3-7) | |
| Nov. 23 at Cleveland Browns 1 p.m. | W 16-6 (4-7) | |
| Dec. 1 (Mon.) Jacksonville Jaguars 8:30 p.m. | W 30-17 (5-7) | |
| Dec. 7 at Green Bay Packers 1 p.m. | W 24-21 (6-7) | |
| Dec. 14 Tennessee Titans 1 p.m. | ||
| Dec. 21 at Oakland Raiders 4:05 p.m. | ||
| Dec. 28 Chicago Bears 1 p.m. | ||
| Sun. 9/9 vs. Chiefs | W 20-3 (1-0) | |
| Sun. 9/16 @ Panthers | W 34-21 (2-0) | |
| Sun. 9/23 vs. Colts | L 24-30 (2-1) | |
| Sun. 9/30 @ Falcons | L 16-26 (2-2) | |
| Sun. 10/7 vs. Dolphins | W 22-19 (3-2) | |
| Sun. 10/14 @ Jaguars | L 17-37 (3-3) | |
| Sun. 10/21 vs. Titans | L 36-38 (3-4) | |
| Sun. 10/28 @ Chargers | L 10-35 (3-5) | |
| Sun. 11/4 @ Raiders | W 24-17 (4-5) | |
| Sun. 11/11 Bye | Bye | |
| Sun. 11/18 vs. Saints | W 32-10 (5-5) | |
| Sun. 11/25 @ Browns | L 17-27 (5-6) | |
| Sun. 12/2 @ Titans | L 20-28 (5-7) | |
| Sun. 12/9 vs. Buccaneers | W 28-14 (6-7) | |
| Thu. 12/13 vs. Broncos | W 31-13 (7-7) | |
| Sun. 12/23 @ Colts | L 15-38 (7-8) | |
| Sun. 12/30 vs. Jaguars | W 42-28 (8-8) | |