| Sep 09 MIN @ NO | 8:30 PM | |
| Sep 20 NO @ SF | 8:30 PM | |
| Sep 26 ATL @ NO | 1:00 PM | |
| Oct 03 CAR @ NO | 1:00 PM | |
| Oct 10 NO @ ARI | 4:05 PM | |
| Oct 17 NO @ TB | 1:00 PM | |
| Oct 24 CLE @ NO | 1:00 PM | |
| Oct 31 PIT @ NO | 8:20 PM | |
| Nov 07 NO @ CAR | 1:00 PM | |
| Bye | - | |
| Nov 21 SEA @ NO | 4:05 PM | |
| Nov 25 NO @ DAL | 4:15 PM | |
| Dec 05 NO @ CIN | 1:00 PM | |
| Dec 12 STL @ NO | 4:05 PM | |
| Dec 19 NO @ BAL | 1:00 PM | |
| Dec 27 NO @ ATL | 8:30 PM | |
| Jan 02 TB @ NO | 1:00 PM | |
| Sep 13 DET @ NO | W 45-27 (1-0) | |
| Sep 20 NO @ PHI | W 48-22 (2-0) | |
| Sep 27 NO @ BUF | W 27-7 (3-0) | |
| Oct 04 NYJ @ NO | W 24-10 (4-0) | |
| Bye | Bye | |
| Oct 18 NYG @ NO | W 48-27 (5-0) | |
| Oct 25 NO @ MIA | W 46-34 (6-0) | |
| Nov 02 ATL @ NO | W 35-27 (7-0) | |
| Nov 08 CAR @ NO | W 30-20 (8-0) | |
| Nov 15 NO @ STL | W 28-23 (9-0) | |
| Nov 22 NO @ TB | W 38-7 (10-0) | |
| Nov 30 NE @ NO | W 38-17 (11-0) | |
| Dec 06 NO @ WAS | W 33-30 (12-0) | |
| Dec 13 NO @ ATL | W 26-23 (13-0) | |
| Dec 19 DAL @ NO | L 24-17 (13-1) | |
| Dec 27 TB @ NO | L 20-17 (13-2) | |
| Jan 03 NO @ CAR | L 10-23 (13-3) | |
| Jan 16 ARI@NO Divisional | W 45-14 (14-3) | |
| Jan 24 MIN @ NO Conference | W 31-28 (15-3) | |
| Feb 07 NO @ IND Superbowl | W 31-17 (16-3) | |
| Sept. 7 Tampa Bay Buccaneers 1 p.m. | W 24-20 (1-0) | |
| Sept. 14 at Washington Redskins 1 p.m. | L 24-29 (1-1) | |
| Sept. 21 at Denver Broncos 4:05 p.m. | L 32-24 (1-2) | |
| Sept. 28 San Francisco 49ers 1 p.m. | W 31-17 (2-2) | |
| Oct. 6 (Mon.) Minnesota Vikings 8:30 p.m. | L 27-30 (2-3) | |
| Oct. 12 Oakland Raiders 1 p.m. | W 34-3 (3-3) | |
| Oct. 19 at Carolina Panthers 1 p.m. | L 7-30 (3-4) | |
| Oct. 26 San Diego Chargers (in London) 1 p.m. | W 37-32 (4-4) | |
| Nov. 2 Bye | Bye | |
| Nov. 9 at Atlanta Falcons 1 p.m. | L 20-34 (4-5) | |
| Nov. 16 at Kansas City Chiefs 1 p.m. | W 30-20 (5-5) | |
| Nov. 24 (Mon.) Green Bay Packers 8:30 p.m. | W 51-29 (6-5) | |
| Nov. 30 at Tampa Bay Buccaneers 1 p.m. | L 20-23 (6-6) | |
| Dec. 7 Atlanta Falcons 1 p.m. | W 29-25 (7-6) | |
| Dec. 11 (Thurs.) at Chicago Bears 8:15 p.m. | L 24-27 OT (7-7) | |
| Dec. 21 at Detroit Lions 1 p.m. | W 42-7 (8-7) | |
| Dec. 28 Carolina Panthers 1 p.m. | L 31-33 (8-8) | |
| Sep 6 @Indianapolis | L 10-41 (0-1) | |
| Sep 16 @Tampa Bay | L 14-31 (0-2) | |
| Sep 24 Tennessee | L 14-31 (0-3) | |
| BYE | BYE | |
| Oct 7 Carolina | L 13-16 (0-4) | |
| Oct 14 @Seattle | W 28-17 (1-4) | |
| Oct 21 Atlanta | W 22-16 (2-4) | |
| Oct 28 @San Francisco | W 31-10 (3-4) | |
| Nov 4 Jacksonville | W 41-24 (4-4) | |
| Nov 11 St. Louis | L 29-37 (4-5) | |
| Nov 18 @Houston | L 10-23 (4-6) | |
| Nov 25 @Carolina | W 31-6 (5-6) | |
| Dec 2 Tampa Bay | L 23-27 (5-7) | |
| Dec 10 @Atlanta | W 34-14 (6-7) | |
| Dec 16 Arizona | W 31-24 (7-7) | |
| Dec 23 Philadelphia | L 23-38 (7-8) | |
| Dec 30 @Chicago | L 25-33 (7-9) | |