| Sep 12 SF @ SEA | 4:15 PM | |
| Sep 19 SEA @ DEN | 4:05 PM | |
| Sep 26 SD @ SEA | 4:15 PM | |
| Oct 03 SEA @ STL | 1:00 PM | |
| Bye | - | |
| Oct 17 SEA @ CHI | 1:00 PM | |
| Oct 24 ARI @ SEA | 4:05 PM | |
| Oct 31 SEA @ OAK | 4:15 PM | |
| Nov 07 NYG @ SEA | 4:05 PM | |
| Nov 14 SEA @ ARI | 4:15 PM | |
| Nov 21 SEA @ NO | 4:05 PM | |
| Nov 28 KC @ SEA | 4:05 PM | |
| Dec 05 CAR @ SEA | 4:15 PM | |
| Dec 12 SEA @ SF | 4:05 PM | |
| Dec 19 ATL @ SEA | 4:05 PM | |
| Dec 26 SEA @ TB | 1:00 PM | |
| Jan 02 STL @ SEA | 4:15 PM | |
| Sep 13 STL @ SEA | W 28-0 (1-0) | |
| Sep 20 SEA @ SF | L 10-23 (1-1) | |
| Sep 27 CHI @ SEA | L 19-25 (1-2) | |
| Oct 04 SEA @ IND | L 17-34 (1-3) | |
| Oct 11 JAC @ SEA | W 41-0 (2-3) | |
| Oct 18 ARI @ SEA | L 3-27 (2-4) | |
| Bye | Bye | |
| Nov 01 SEA @ DAL | L 17-38 (2-5) | |
| Nov 08 DET @ SEA | W 32-20 (3-5) | |
| Nov 15 SEA @ ARI | L 20-31 (3-6) | |
| Nov 22 SEA @ MIN | L 9-35 (3-7) | |
| Nov 29 SEA @ STL | W 27-17 (4-7) | |
| Dec 06 SF @ SEA | W 20-17 (5-7) | |
| Dec 13 SEA @ HOU | L 7-34 (5-8) | |
| Dec 20 TB @ SEA | L 7-24 (5-9) | |
| Dec 27 SEA @ GB | L 10-48 (5-10) | |
| Jan 03 TEN @ SEA | L 13-17 (5-11) | |
| Sept. 7 at Buffalo Bills 1 p.m. | L 10-34 (0-1) | |
| Sept. 14 San Francisco 49ers 4:05 p.m. | L 30-33 (0-2) | |
| Sept. 21 St. Louis Rams 4:05 p.m. | W 37-13 (1-2) | |
| Sept. 28 Bye | Bye | |
| Oct. 5 at New York Giants 1 p.m. | L 6-44 (1-3) | |
| Oct. 12 Green Bay Packers 4:15 p.m. | L 17-27 (1-4) | |
| Oct. 19 at Tampa Bay Buccaneers 8:15 p.m. | L 10-20 (1-5) | |
| Oct. 26 at San Francisco 49ers 4:15 p.m. | W 34-13 (2-5) | |
| Nov. 2 Philadelphia Eagles 4:15 p.m. | L 7-26 (2-6) | |
| Nov. 9 at Miami Dolphins 1 p.m. | L 19-21 (2-7) | |
| Nov. 16 Arizona Cardinals 4:05 p.m. | L 20-26 (2-8) | |
| Nov. 23 Washington Redskins 4:15 p.m. | L 17-20 (2-9) | |
| Nov. 27 (Thurs.) at Dallas Cowboys 4:15 p.m. | L 9-34 (2-10) | |
| Dec. 7 New England Patriots 8:15 p.m. | L 21-24 (2-11) | |
| Dec. 14 at St. Louis Rams 1 p.m. | ||
| Dec. 21 New York Jets 4:05 p.m. | ||
| Dec. 28 at Arizona Cardinals 4:15 p.m. | ||
| Sep 9 Tampa Bay 4:15pm | W 20-6 (1-0) | |
| Sep 16 @Arizona 4:05pm | L 20-23 (1-1) | |
| Sep 23 Cincinnati 4:05pm | W 24-21 (2-1) | |
| Sep 30 @San Francisco 4:05pm | W 23-3 (3-1) | |
| Oct 7 @Pittsburgh 1:00pm | L 0-21 (3-2) | |
| Oct 14 New Orleans 8:15pm | L 17-28 (3-3) | |
| Oct 21 St. Louis 4:15pm | W 33-6 (4-3) | |
| BYE | BYE | |
| Nov 4 @Cleveland 4:05pm | L 30-33 (4-4) | |
| Nov 12 San Francisco 8:30pm | W 24-0 (5-4) | |
| Nov 18 Chicago 8:15pm | W 30-23 (6-4) | |
| Nov 25 @St. Louis 1:00pm | W 24-19 (7-4) | |
| Dec 2 @Philadelphia 1:00pm | W 28-24 (8-4) | |
| Dec 9 Arizona 4:05pm | W 42-21 (9-4) | |
| Dec 16 @Carolina 1:00pm | L 10-13 (9-5) | |
| Dec 23 Baltimore 4:15pm | W 27-6 (10-5) | |
| Dec 30 @Atlanta 1:00pm | L 41-44 (10-6) | |